A Randomized, Open-Label, Phase 3 Study to Evaluate Zimberelimab and Domvanalimab in Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy for the First-Line Treatment of Patients With Metastatic Non-Small Cell Lung Cancer With No Epidermal Growth Factor Receptor or Anaplastic Lymphoma Kinase Genomic Tumor Aberrations (STAR-121)
The primary objective of this study is to compare the effect of zimberelimab (ZIM) and domvanalimab (DOM) in combination with chemotherapy relative to pembrolizumab (PEMBRO) in combination with chemotherapy on progression-free survival (PFS) and overall survival (OS) in patients with untreated metastatic non-small cell lung cancer with no actionable genomic alteration.
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Age
18 Years +
Sex
All
Healthy Volunteers
No
Medical Condition
Non-small Cell Lung Cancer
Gender
N/A
Date
October 2022 - September 2027
Study Type
Interventional
Study Phase
Phase 3
Product
Zimberelimab, Domvanalimab, Pembrolizumab, Carboplatin, Cisplatin, Paclitaxel, Nab-paclitaxel, Pemetrexed
Glendale, Arizona, United States, 85304
San Marcos, California, United States, 92069
Santa Barbara, California, United States, 93105
Whittier, California, United States, 90606
Norwich, Connecticut, United States, 06360
Lake City, Florida, United States, 32024
Sarasota, Florida, United States, 34232
Tampa, Florida, United States, 33612
Atlanta, Georgia, United States, 30318
Peoria, Illinois, United States, 61615
Asheville, North Carolina, United States, 28806
Cincinnati, Ohio, United States, 45242
Eugene, Oregon, United States, 97401
Pittsburgh, Pennsylvania, United States, 15212
Arlington, Texas, United States, 76012
Austin, Texas, United States, 78745
Dallas, Texas, United States, 75246
Sherman, Texas, United States, 75090
Arlington, Virginia, United States, 22205
Blacksburg, Virginia, United States, 24060
Vancouver, Washington, United States, 98684
Capital, Argentina, F5300COE
Cardoba, Argentina, X5008HHW
Ciudad Autanoma Buenos Aires, Argentina, 1426
Cordoba, Argentina, 5000
Rosario, Argentina, 2000
Rosario, Argentina, S2000DSV
Rosario, Argentina, S2002KDS
Rosario, Argentina, S2013DTC
San Miguel de Tucumán, Argentina, 4000
Viedma, Argentina, 8500
Klagenfurt Am Woerthersee, Austria
Linz, Austria, 4020
Wels, Austria, 4600
Wien, Austria, A-1140
Aalst, Belgium, 9300
Charleroi, Belgium, 6000
Mechelen, Belgium, 2800
Namur, Belgium, 5000
Belo Horizonte, Brazil, 30130-090
Cachoeiro De Itapemirim, Brazil, 29308-014
Caxias Do Sul, Brazil, 95070-560
Fortaleza, Brazil, 60430-230
Ijui, Brazil, 98700-000
Jau, Brazil, 17210080
Porto Alegre, Brazil, 90020-090
Porto Alegre, Brazil, 90035-903
Porto Alegre, Brazil, 90610-000
Santa Cruz Do Sul, Brazil, 96810-110
Sao Paulo, Brazil, 03102002
Greenfield Park, Canada, J4V 2H1
Moncton, Canada, E1C 6Z8
Quebec, Canada, J7Z 2V4
Rimouski, Canada, G5L5T1
Victoria, Canada, V8R 6V5
Las Condes, Chile, 7550000
Providencia, Chile, 7500006
Providencia, Chile, 7510035
Puerto Montt, Chile, 5500243
Santiago, Chile, 8331143
Temuco, Chile, 4800827
Vina del Mar, Chile, 2520612
Chengdu, China, 610041
Deyang, China, 618000
Shanghai, China, 200433
Shantou, China, 0754-88555844
Wuhan, China, 430022
Xinxiang, China, 453100
Boulogne-Billancourt, France, 92100
Caen, France, 14000
Le Mans, France, 72000
Marseille, France, 13005
Montpellier, France, 34928
Nice, France, 6189
Saint-Herblain, France, 44805
Saint-Mandé, France, 94160
Saint-Quentin, France, 2100
Strasbourg, France, 67033
Suresnes, France, 92150
Toulon cedex, France, 83056
Bochum, Germany, 44791
Chemnitz, Germany, 9116
Essen, Germany, 45122
Freiburg, Germany, 79106
Grosshansdorf, Germany, 22927
Halle, Germany, 06120
Hamburg, Germany, 21075
Hamburg, Germany, 22087
Hemer, Germany, 58675
Karlsruhe, Germany, 76137
Kassel, Germany, 34125
Köln, Germany, 51109
Lubeck, Germany, 23538
Minden, Germany, 32429
Munchen, Germany, 81925
Offenbach, Germany, 63069
Hong Kong, Hong Kong, 999077
Hong Kong, Hong Kong
New Territories, Hong Kong
Beer Seva, Israel, 84101
Jerusalem, Israel, 9103102
Nahariya, Israel
Petah Tiqva, Israel, 49100
Rehovot, Israel, 76100
Tel Aviv, Israel, 64239
Avellino, Italy
Candiolo, Italy, 10060
Cremona, Italy, 26100
Genova, Italy, 16132
Milano, Italy, 20132
Modena, Italy, 41124
Naples, Italy, 80131
Napoli, Italy, 80131
Pavia, Italy, 27100
Pesaro, Italy, 61122
Piacenza, Italy, 29100
Pordenone, Italy, 33081
Rome, Italy, 00144
Treviglio, Italy, 24047
Chiba, Japan, 277-0882
Ehime, Japan, 791-0280
Fukuoka, Japan, 812-8582
Fukuoka, Japan, 830-0011
Hyogo, Japan, 670-8520
Hyogo, Japan, 673-8558
Ishikawa, Japan, 920-8641
Kanagawa, Japan, 241-0815
Miyagi, Japan, 980-0873
Niigata, Japan, 951-8566
Osaka, Japan, 545-8586
Osaka, Japan, 569-8686
Osaka, Japan, 589-8511
Osaka, Japan, 591-8555
Saitama, Japan, 350-1298
Dongjak-Gu, Korea, Republic of, 07061
Gangnam-Gu, Korea, Republic of, 6351
Goyang, Korea, Republic of, 410769
Heungdeok-Gu, Korea, Republic of, 361-711
Incheon, Korea, Republic of, 22332
Inchon, Korea, Republic of, 21565
Seo-gu, Korea, Republic of, 49267
Seoul, Korea, Republic of, 03722
Seoul, Korea, Republic of, 05505
Seoul, Korea, Republic of, 06591
Suwon-si, Korea, Republic of, 16499
Suwon, Korea, Republic of, 16247
Mexico, Mexico, 3100
Mitras Centro, Mexico, 64460
Oaxaca, Mexico, 68000
Oaxaca, Mexico, 68020
Orizaba Centro, Mexico, 94300
Puebla, Mexico, 72530
Veracruz, Mexico, 91900
Breda, Netherlands, 4818 CK
Ede, Netherlands, 6716 RP
Groningen, Netherlands, 9713 GZ
Harderwijk, Netherlands, 3844 DG
Tilburg, Netherlands
Amadora, Portugal, 2720276
Lisboa, Portugal, 1089
Lisboa, Portugal, 1400-038
Lisboa, Portugal
Lisbon, Portugal, 2674-514
Porto, Portugal, 4202-451
Senhora da Hora, Portugal, 4464-513
Singapore, Singapore, 188770
Singapore, Singapore, 308433
Barcelona, Spain, 08036
Barcelona, Spain, 08041
Barcelona, Spain, 8028
Barcelona, Spain, 8035
Barcelona, Spain, 8208
Cordoba, Spain, 14004
Girona, Spain, 17007
Jaen, Spain, 23007
Las Palmas de G.C., Spain, 35016
Madrid, Spain, 28020
Madrid, Spain, 28027
Madrid, Spain, 28046
Majadahonda, Spain, 28222
Reus, Spain, 43204
Rincon de la Victoria, Spain, 29011
Sevilla, Spain, 41009
Seville, Spain, 41014
Valencia, Spain, 46009
Valencia, Spain, 46015
Valencia, Spain, 46015
Changhua City, Taiwan, 500-06
Kaohsiung City, Taiwan, 824
Kaohsiung, Taiwan, 807
Kaohsiung, Taiwan, 83301
Tainan, Taiwan, 70403
Tainan, Taiwan
Taipei City, Taiwan, 100
Taipei, Taiwan, 10002
Taoyuan City, Taiwan, 33305
Ankara, Turkey, 06550
Ankara, Turkey, 6200
Edirne, Turkey, 22030
Fatih, Turkey, 34098
Istanbul, Turkey, 34093
Istanbul, Turkey
Kaakaekmece, Turkey, 34303
Malatya, Turkey, 44300
Colchester, United Kingdom, CO4 5JL
London, United Kingdom, EC1A 7BE
Southampton, United Kingdom, SO16 6YD
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