Advancing research for potential respiratory syncytial virus (RSV) treatment

For over 35 years, Gilead has been focused on researching antiviral treatments that can make a difference in the lives of patients. We're always testing new medicines to make sure they're both safe and effective for people of all ages. Our goal is to find treatments for RSV to give patients and their families hope and confidence when it comes to treatment.

Every year in the US, RSV leads to about

60,000–160,000

hospitalizations and 6,000–10,000 deaths in adults 65 years or older

58,000–80,000

hospitalizations and an estimated 100–300 deaths in children under 5 years old

About RSV

What is RSV?

The RSV is a common virus that affects the nose, throat, lungs, and airways. RSV is transmitted through droplets when someone with the virus coughs, sneezes, or kisses. It's also possible to contract RSV by touching a surface that has the virus on it, and then touching the eyes, nose, or mouth. A person with RSV is most likely to spread the virus, or be contagious, during the first week after infection. RSV usually has mild symptoms that are like the common cold: congested or runny nose, dry cough, fever, sore throat, sneezing, and/or headache. However, in some people, RSV can be more serious. In most parts of the US, RSV season usually begins in November and goes through March.

Sources: National Foundation for Infectious Disease, Mayo Clinic,
MedlinePlus

Understanding RSV risk and exploring clinical trial options

While anyone at any age is at risk of RSV, infants and older people have a higher risk of having a severe RSV infection and may need hospitalization.

Adults at high risk for severe RSV:

  • Over 60 years old
  • Have chronic heart or lung disease
  • Have weakened immune systems

If you are 18 years or older, have RSV, are not currently hospitalized, and are at high risk for severe RSV, you may be eligible for a study.

Children at high risk for severe RSV:

  • Premature infants
  • Infants under 12 months
  • Children under 2 years with chronic lung disease or congenital heart disease
  • Children with weakened immune systems
  • Children with neuromuscular disorders

If your child is under 5 years old, has RSV, and is not currently hospitalized, they may be eligible for a study.

Sources: Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, Centers for Disease Control and Prevention

RSV diagnosis

If RSV is suspected, laboratory tests may be suggested to confirm this diagnosis. The most common are the rapid antigen test and PCR test.

1

Rapid antigen test

  • Sample of fluid taken from the nose
  • Only effective in infants and younger children
2

PCR test

  • Swab taken from the nose
  • Should be used to test older children and adults

Timely RSV testing is especially important in infants and older adults because the doctor can confirm the cause of their symptoms and assess whether a treatment or clinical trial may be appropriate. If the test comes back positive, infants and older adults may need treatment in the hospital right away if they have more serious symptoms.

Sources: MedlinePlus, Centers for Disease Control and Prevention

RSV treatment and prevention

Currently, there are no FDA-approved oral medications for treatment available for RSV.

To help prevent severe RSV, vaccines are available for older adults and pregnant people and monoclonal antibody products are available for infants and young children. But even after vaccination or immunization, adults, children, and infants can get RSV and may need treatment.

Over-the-counter medications can help manage symptoms such as fever and discomfort. A doctor may recommend nasal saline drops or a suction tool to help clear up a stuffy nose. If an RSV infection becomes severe and requires hospitalization, oxygen or IV fluids may be needed for treatment.

Mild RSV infections tend to clear up on their own in about 1 to 2 weeks without any treatment.

Sources: American Lung Association, Centers for Disease Control and Prevention

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