Study Details

OVERVIEW

A Phase 2, Randomized, Double-Blind, Double-Dummy, Placebo-Controlled Study Evaluating the Safety and Efficacy of Semaglutide, and the Fixed-Dose Combination of Cilofexor and Firsocostat, Alone and in Combination, in Subjects With Compensated Cirrhosis (F4) Due to Nonalcoholic Steatohepatitis (NASH) (WAYFIND)

PROTOCOL SUMMARY

The goals of this clinical study are to learn more about the study drugs, semaglutide (SEMA) with the fixed-dose combination (FDC) of cilofexor/firsocostat (CILO/FIR), and understand whether they cause fibrosis improvement and Nonalcoholic Steatohepatitis (NASH) resolution in participants with cirrhosis due to NASH.

Participation Requirements

Age

18 Years - 80 Years

Sex

All

Healthy Volunteers

Medical Condition

Nonalcoholic Steatohepatitis

Gender

N/A

Date

August 2021 - November 2024

Study Type

Interventional

Study Phase

Phase 2

Product

Semaglutide (SEMA), Cilofexor (CILO)/Firsocostat (FIR), PTM SEMA, PTM CILO/FIR

Eligibility Information

Inclusion Criteria

Liver biopsy consistent with cirrhosis (F4) due to nonalcoholic steatohepatitis (NASH) in the opinion of the central reader. In individuals who have never had a liver biopsy, a screening liver biopsy may be performed.
Screening laboratory parameters as determined by the study central laboratory:
Estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73m^2, as calculated by the Modification of Diet in Renal Disease (MDRD) equation.
HbA1c ≤ 10%
International normalized ratio (INR) ≤ 1.4, unless due to therapeutic anticoagulation
Platelet count ≥ 125,000/uL
Alanine aminotransferase (ALT) < 5 x ULN
Serum albumin ≥ 3.5 g/dL
Serum alkaline phosphatase (ALP) ≤ 2 x ULN
Body mass index (BMI) ≥ 23 kg/m^2 at screening.

Exclusion Criteria

Prior history of decompensated liver disease, including ascites, hepatic encephalopathy (HE), or variceal bleeding.
Child-Pugh (CP) score > 6 at screening, unless due to an alternative etiology such as Gilbert's syndrome or therapeutic anticoagulation.
Model for End-stage Liver Disease (MELD) score > 12 at screening, unless due to an alternative etiology such as therapeutic anticoagulation.
Other causes of liver disease based on medical history and/or central reader review of liver histology, including but not limited to: alcoholic liver disease, autoimmune disorders (eg, primary biliary cholangitis, primary sclerosing cholangitis, autoimmune hepatitis), drug-induced hepatotoxicity, Wilson disease, clinically significant iron overload, or alpha-1-antitrypsin deficiency.
Chronic hepatitis B virus (HBV) infection (HBsAg positive), or Chronic hepatitis C virus (HCV) infection (HCV antibody and HCV ribonucleic acid (RNA) positive). Individuals cured of HCV infection less than 2 years prior to the screening visit are not eligible.
History of liver transplantation.
Current or prior history of hepatocellular carcinoma (HCC).
Men who habitually drink greater than 21 units/week of alcohol or women who habitually drink greater than 14 units/week of alcohol (1 unit is equivalent to 12 ounce (oz)/360 mL of beer, a 4 oz/120 mL glass of wine, or 1 oz/30 mL of hard liquor).
For individuals on vitamin E regimen ≥ 800 IU/day, or pioglitazone, dose must be stable, in the opinion of the investigator for at least 180 days prior to the historical or screening liver biopsy.
For individuals on medications for diabetes, dose must be stable, in the opinion of the investigator, for at least 90 days prior to the historical or screening liver biopsy.
History of type 1 diabetes.
Treatment with a glucagon-like peptide-1 receptor agonist (GLP-1 RA) in the period from 90 days prior to the screening visit and for individuals with a qualifying historical liver biopsy, for 90 days prior to the date of the historical liver biopsy.
For individuals who have not completed a series of an authorized coronavirus disease 2019 (COVID-19) vaccination regimen prior to screening, a positive result for COVID-19 on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcriptase-polymerase chain reaction (RT-PCR) test.
Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Locations

Locations (242)

University of Alabama at Birmingham Hospital

Birmingham, Alabama, United States, 35233

Digestive Health Specialists

Dothan, Alabama, United States, 36305

North Alabama Health Research, LLC

Madison, Alabama, United States, 35758

The Institution For Liver Health dba Arizona Liver Health

Chandler, Arizona, United States, 85224

Arizona Health Research

Chandler, Arizona, United States, 85225

The Institute for Liver Health DBA Arizona Liver Health

Peoria, Arizona, United States, 85381

Gastrointestinal Alliance - Sun City

Sun City, Arizona, United States, 85351

Adobe Clinical Research, LLC

Tucson, Arizona, United States, 85712

The Institution For Liver Health dba Arizona Liver Health

Tucson, Arizona, United States, 85712

Arkansas Diagnostic Center

Little Rock, Arkansas, United States, 72204

ARCare Center for Clinical Research

Little Rock, Arkansas, United States, 72205

Arkansas Gastroenterology

North Little Rock, Arkansas, United States, 72117

Southern California Research Center

Coronado, California, United States, 92118

University of California, San Francisco - Fresno

Fresno, California, United States, 93701

University of California, San Diego - Altman Clinical and Translational Research Institute

La Jolla, California, United States, 92037

Gastro Care Institute (Fibroscan)

Lancaster, California, United States, 93534

Digestive Health Research of Southern California

Long Beach, California, United States, 90808

Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, United States, 90027

Keck Medical Center of USC Healthcare Consultation II

Los Angeles, California, United States, 90033

Biopharma Informatic, LLC

Los Angeles, California, United States, 90035

United Medical Doctors

Murrieta, California, United States, 92563

Knowledge Research Center

Orange, California, United States, 92868

Palmtree Clinical Research, Inc.

Palm Springs, California, United States, 92262

California Liver Research Institute

Pasadena, California, United States, 91105

Cadena Care Institute, LLC

Poway, California, United States, 92064

Stanford Medicine Outpatient Center

Redwood City, California, United States, 94063

Inland Empire Clinical Trials

Rialto, California, United States, 92377

University of California, Davis Medical Center

Sacramento, California, United States, 95817

Research and Education Inc.

San Diego, California, United States, 92105

TriWest Research Associates, LLC

San Diego, California, United States, 92108

Precision Research Institute

San Diego, California, United States, 92114

Medical Associates Research Group

San Diego, California, United States, 92123

Quest Clinical Research

San Francisco, California, United States, 94115

University of California, San Francisco - Liver Clinic

San Francisco, California, United States, 94143

San Jose Gastroenterology at One Health

San Jose, California, United States, 95128

University of Colorado Anschutz Medical Campus

Aurora, Colorado, United States, 80045

South Denver Gastroenterology

Englewood, Colorado, United States, 80113

Yale Center for Clinical Investigation, Church Street Research Unit

New Haven, Connecticut, United States, 06519

Excel Medical Clinical Trials, LLC

Boca Raton, Florida, United States, 33434

Synergy Healthcare

Bradenton, Florida, United States, 34208

Southwest General Healthcare Center

Fort Myers, Florida, United States, 33907

University of Florida Hepatology Research at the Clinical and Translational Research Building

Gainesville, Florida, United States, 32610

Velocity Clinical Research, Hallandale Beach

Hallandale Beach, Florida, United States, 33009

Evolution Clinical Research, INC

Hialeah Gardens, Florida, United States, 33016

Indago Research and Health Center, Inc.

Hialeah, Florida, United States, 33012

Maya Research Center

Hialeah, Florida, United States, 33016

New Generation of Medical Research

Hialeah, Florida, United States, 33016

Sunbright Health Medical Center

Homestead, Florida, United States, 33032

Nature Coast Clinical Research

Inverness, Florida, United States, 34452

UF Health Jacksonville-Gastroenterology Emerson

Jacksonville, Florida, United States, 32224

Encore Borland-Groover Clinical Research

Jacksonville, Florida, United States, 32256

Florida Research Institute

Lakewood Ranch, Florida, United States, 34211

Ocean Blue Medical Research Center, Inc

Miami Springs, Florida, United States, 33166

G+C Research Group

Miami, Florida, United States, 33126

Schiff Center for Liver Diseases/ University of Miami

Miami, Florida, United States, 33136

Advanced Pharma CR, LLC

Miami, Florida, United States, 33147

Century Research, LLC

Miami, Florida, United States, 33173

ProLive Medical Research, Corp

Miami, Florida, United States, 33175

International Medical Investigational Centers, Inc.

Miami, Florida, United States, 33176

Gastroenterology Group of Naples

Naples, Florida, United States, 34102

Advanced Research Institute, Inc.

New Port Richey, Florida, United States, 34653

Ocala GI Research

Ocala, Florida, United States, 34471

Advanced Medical Research Center

Port Orange, Florida, United States, 32127

Progressive Medical Research

Port Orange, Florida, United States, 32127

Covenant Metabolic Specialists, LLC

Sarasota, Florida, United States, 34240

Charter Research

Winter Park, Florida, United States, 32792

Florida Medical Clinic, LLC

Zephyrhills, Florida, United States, 33542

Southeast Clinical Research LLC

Dalton, Georgia, United States, 30720

Gastrointestinal (GI) Specialists of Georgia

Marietta, Georgia, United States, 30060

Rush University Medical Group - Department of Hepatology

Chicago, Illinois, United States, 60612

Indiana University Health Enterprise Clinical Research Operations

Indianapolis, Indiana, United States, 46202

Gastroenterology Health Partners, PLLC

New Albany, Indiana, United States, 47150

Digestive Research Alliance of Michigan

South Bend, Indiana, United States, 44635

Iowa Digestive Disease Center, PC

Clive, Iowa, United States, 50325

University of Iowa Hospitals and Clinics

Iowa City, Iowa, United States, 52242

University of Kansas Medical Center

Kansas City, Kansas, United States, 66160

Kansas Medical Clinic PA

Topeka, Kansas, United States, 66606

GI Alliance

Baton Rouge, Louisiana, United States, 70809

Combined Gastro Research, LLC

Lafayette, Louisiana, United States, 70503

Tandem Clinical Research GI, LLC

Marrero, Louisiana, United States, 70072

Delta Research Partners

Monroe, Louisiana, United States, 71201

Tulane University Health Sciences Center

New Orleans, Louisiana, United States, 70112

Oschner Clinic Foundation

New Orleans, Louisiana, United States, 70121

Louisiana Research Center, LLC

Shreveport, Louisiana, United States, 71105

Mercy Medical Center

Baltimore, Maryland, United States, 21202

Walter Reed National Military Medical Center

Bethesda, Maryland, United States, 20889

Woodholme Gastroenterology Associates

Glen Burnie, Maryland, United States, 21061

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States, 02215

Greater Boston Gastroenterology

Framingham, Massachusetts, United States, 01702

Hawthorn Medical Associates

South Dartmouth, Massachusetts, United States, 02747

Michigan Medicine - University of Michigan

Ann Arbor, Michigan, United States, 48109

Clinical Research Institute of Michigan, LLC

Chesterfield, Michigan, United States, 48047

Henry Ford Health System

Detroit, Michigan, United States, 48202

Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center

Wyoming, Michigan, United States, 49519

Huron Gastroenterology Associates

Ypsilanti, Michigan, United States, 48197

Mayo Clinic

Rochester, Minnesota, United States, 55905

GI Alliance

Flowood, Mississippi, United States, 39232

Southern Therapy and Advanced Research

Jackson, Mississippi, United States, 39216

Clinical Research Professionals

Chesterfield, Missouri, United States, 63005

GI Associates Research

Columbia, Missouri, United States, 65201

Kansas City Research Institute

Kansas City, Missouri, United States, 64131

Sierra Clinical Research

Las Vegas, Nevada, United States, 89106

Digestive Disease Research

Florham Park, New Jersey, United States, 07932

Allied Health Clinical Research Organization, LLC

Freehold, New Jersey, United States, 07728

Rutgers New Jersey Medical School

Newark, New Jersey, United States, 07103

Center for Research at Southwest Gastroenterology Associates, PC

Albuquerque, New Mexico, United States, 87109

Northwell Health Center for Liver Diseases

Manhasset, New York, United States, 11030

New York University Langone Health

New York, New York, United States, 10016

Mount Sinai Medical Center

New York, New York, United States, 10029

Liver Clinic (study visits, Fibroscan): Columbia University Irving Medical Center / NewYork Presbyterian Hospital

New York, New York, United States, 10032

The New York - Presbyterian Hospital

New York, New York, United States, 10065

University of Rochester Medical Center

Rochester, New York, United States, 14642

Asheville Gastroenterology, a Division of Digestive Health Partners, PA

Asheville, North Carolina, United States, 28801

Atrium Health Transplant and Center for Liver Disease

Charlotte, North Carolina, United States, 28204

Charlotte Gastroenterology & Hepatology, PLLC

Charlotte, North Carolina, United States, 28207

Northeast GI Research Division

Concord, North Carolina, United States, 28027

Coastal Research Institute

Fayetteville, North Carolina, United States, 28304

Lucas Research, Inc.

Morehead City, North Carolina, United States, 28557

Carolina's GI Research, LLC

Raleigh, North Carolina, United States, 27607

Optimed Research

Columbus, Ohio, United States, 43235

DSI Research

Springboro, Ohio, United States, 45066

Clinical Research Institute of Ohio, LLC

Westlake, Ohio, United States, 44145

Options Health Research, LLC

Tulsa, Oklahoma, United States, 74104

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States, 15213

Velocity Clinical Research - Providence

East Greenwich, Rhode Island, United States, 02818

University Gastroenterology

Providence, Rhode Island, United States, 02905

Medical University of South Carolina

Charleston, South Carolina, United States, 29425

Columbia Digestive Health Research

Columbia, South Carolina, United States, 29204

Digestive Disease Research Center

Greenwood, South Carolina, United States, 29646

Velocity Clinical Research, Spartanburg

Spartanburg, South Carolina, United States, 29303

Wake Research - ClinsSearch, LLC

Chattanooga, Tennessee, United States, 37421

Gastrointestinal Associates of Northeast Tennessee

Johnson City, Tennessee, United States, 37604

Quality Medical Research, PLLC

Nashville, Tennessee, United States, 37211

Texas Clinical Research Institute

Arlington, Texas, United States, 76012

Pinnacle Clinical Research

Austin, Texas, United States, 78757

South Texas Research Institute

Brownsville, Texas, United States, 78520

GI Alliance

Cedar Park, Texas, United States, 78613

The Liver Institute at Methodist Dallas Medical Center

Dallas, Texas, United States, 75203

GI Alliance

Dallas, Texas, United States, 75246

Internal Medicine Digestive and Liver Diseases Clinical Trials

Dallas, Texas, United States, 75390

Soma Clinical Trials, LLC

Denison, Texas, United States, 75020

DHR Health Institute for Research and Development Cancer Research Center

Edinburg, Texas, United States, 78539

South Texas Research Institute

Edinburg, Texas, United States, 78539

GI Alliance

Fort Worth, Texas, United States, 76104

GI Alliance

Garland, Texas, United States, 75044

Pinnacle Clinical Research

Georgetown, Texas, United States, 78626

Texas Digestive Specialists

Harlingen, Texas, United States, 78550

Houston Methodist Hospital

Houston, Texas, United States, 77030

Liver Associates of Texas, P.A.

Houston, Texas, United States, 77030

Liver Specialists of Texas

Houston, Texas, United States, 77030

Biopharma Informatic, LLC

Houston, Texas, United States, 77043

Houston Research Institute

Houston, Texas, United States, 77079

Biopharma Informatic, LLC

Houston, Texas, United States, 77084

BioStar Clinical Research Group Inc.

Katy, Texas, United States, 77494

GI Alliance

Lubbock, Texas, United States, 79410

Biopharma Informatic, LLC

McAllen, Texas, United States, 78503

Digestive System Healthcare

Pasadena, Texas, United States, 77505

American Research Corporation at the Texas Liver Institute

San Antonio, Texas, United States, 78215

Diabetes and Glandular Disease Clinic, P.A.

San Antonio, Texas, United States, 78229

Pinnacle Clinical Research, LLC

San Antonio, Texas, United States, 78229

GI Alliance (Patients Seen, IP Shipment & Fibroscan)

San Marcos, Texas, United States, 78666

Impact Research Institute

Waco, Texas, United States, 76710

GI Alliance

Webster, Texas, United States, 77598

Digestive Health Research of North Texas

Wichita Falls, Texas, United States, 07960

Intermountain Medical Center

Murray, Utah, United States, 84107

University of Utah Hospital

Salt Lake City, Utah, United States, 84132

Velocity Clinical Research, Salt Lake City

West Jordan, Utah, United States, 84088

The University Of Vermont Medical Center

Burlington, Vermont, United States, 05401

University of Virginia Medical Center

Charlottesville, Virginia, United States, 22908

Manassas Clinical Research Center

Manassas, Virginia, United States, 20110

Digestive and Liver Disease Specialists

Norfolk, Virginia, United States, 23502

Bon Secours Richmond Community Hospital, Inc. d/b/a Bon Secours Liver Institute of Richmond

Richmond, Virginia, United States, 23226

Virginia Commonwealth University Health Clinical Research Services Unit

Richmond, Virginia, United States, 23298

Virginia Mason

Seattle, Washington, United States, 98101

Liver Institute Northwest

Seattle, Washington, United States, 98105

Liverpool Hospital

Liverpool, New South Wales, Australia, 2170

Westmead Hospital

Westmead, New South Wales, Australia, 2145

Royal Brisbane and Women's Hospital

Herston, Queensland, Australia, 4029

Flinders Medical Centre

Adelaide, South Australia, Australia, 5042

Eastern Health, Box Hill Hospital

Box Hill, Victoria, Australia, 3128

Monash Health, Monash Medical Centre (Clayton)

Clayton, Victoria, Australia, 3168

Royal Perth Hospital

Perth, Western Australia, Australia, 6000

Wlliam Osler Health System - Brampton Civic Hospital

Brampton, Canada, L6R 3J7

University of Calgary Liver Unit - Heritage Medical Research Clinic

Calgary, Canada, T2N 4Z6

McMaster University Medical Center

Hamilton, Canada, L8N 3Z5

London Health Sciences Centre - University Hospital

London, Canada, N6A 5A5

Centre de Recherche du Centre Hospitalier de I'Universite de Montreal (CRCHUM)

Montreal, Canada, H2X 0A9

Chronic Viral Illness Service, Royal Victoria Hospital, McGill University Health Centre (MUHC)

Montreal, Canada, H4A 3J1

Toronto General Hospital - University Health Network

Toronto, Canada, M5G 2C4

Toronto Liver Centre

Toronto, Canada, M6H 3M1

Gordon and Leslie Diamond Health Care Centre, Vancouver General Hospital, UBC Division of Gastroenterology

Vancouver, Canada, V5Z 1M9

(G.I.R.I.) Gastrointestinal Research Institute

Vancouver, Canada, V6Z 2K5

Toronto Digestive Disease Associates Specialty Research

Vanghan, Canada, L4L 4Y7

CHU Amiens Picardie

Amiens, France, 80054

Centre Hosptitalier Universitaire d'Angers

Angers, France, 49033

Centre Hospitalier Regional Universitaire de Tours - Hopital Trousseau

Chambray-les-Tours, France, 37170

Hopital Henri Mondor

Creteil, France, 94010

CHU de Grenoble

Grenoble Cedex 9, France, 38043

Hopital Claude Huriez

Lille Cedex, France, 59 037

Centre Hospitalier Universitaire Limoges

Limoges, France, 87042

Hopital de la Croix-Rousse

Lyon, France, 69004

Hopital Saint Joseph

Marseille, France, 13008

Centre Hospitalier Universitarie de Montpellier - Hospital Saint-Eloi

Montpellier, France, 34295

Centre Hospitalier Universitaire de Nice - Hopital L'archet

Nice, France, 06202

Hopital Universitaire Pitie Salpetriere

Paris, France, 75013

Hopitaux de Paris - Hopital Cochin

Paris, France, 75014

Hopital Haut Leveque

Pessac Cedex, France, 33604

Hopital Beaujon

Pessac, France, 33600

CHU Rennes Pontchaillou

Rennes, France, 35000

Hopital Rangueil

Toulouse, France, 31300

Hopital Brabois Adultes - CHU de Nancy

Vandoeuvre les Nancy, France, 54500

Fukui-ken Saiseikai Hospital

Fukui, Japan, 918-8503

Juntendo University Shizouka Hospital

Izunokuni, Japan, 410-2295

University Hospital, Kyoto Prefectural University of Medicine

Kyoto, Japan, 602-8566

Japanese Red Cross Masashino Hospital

Musashino-city, Japan, 1808610

Osaka City University Hospital

Osaka, Japan, 5458586

Saga University Hospital

Saga-shi, Japan, 849-0937

Sapporo-Kosei General Hospital

Sapporo-shi, Japan, 060-0033

Saiseikai Suita Hospital

Suita, Japan, 564-0013

Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital

Tokyo, Japan, 105-8470

Ehime University Hospital

Toon-Shi, Japan, 791-0295

Yamagata University Hospital

Yamagata, Japan, 9909585

Yokohama City University Hospital

Yokohama-shi, Japan, 2360004

Latin Clinical Trial Center

San Juan, Puerto Rico, 00909

VA Caribbean Healthcare System

San Juan, Puerto Rico, 00921

FDI Clinical Research

San Juan, Puerto Rico, 00927

Hospital Germans Trias i Pujol

Badalona, Barcelona, Spain, 08916

Hospital Universitario Torrecardenas

Almeria, Spain, 04009

Hospital del Mar

Barcelona, Spain, 08003

Hospital Universitari Vall d'Hebron

Barcelona, Spain, 08035

Hospital Clinic De Barcelona

Barcelona, Spain, 8036

Hospital General Universiatrio Gregorio Maranon

Madrid, Spain, 28007

Hospital Universitario Ramon y Cajal

Madrid, Spain, 28034

Hospital Universitario La Paz Edificio de Malemidad

Madrid, Spain, 28046

Hospital Universitario Puerta de Hierro-Majadahonda

Majadahonda, Spain, 28222

Complejo Hospitalario de Pontevedra

Pontevedra, Spain, 36071

Hospital Universitario Marques de Valdecilla

Santander, Spain, 39008

Hospital Clinico Universitario de Santiago

Santiago De Compostella, Spain, 15706

Hospital Universitario Virgin del Rocio

Sevilla, Spain, 41013

Consorcio Hospital General Universitario de Valencia

Valencia, Spain, 46014

Hospital Universitario y Politecnlo la Fe

Valencia, Spain, 46026

Hospital Clinico Universitario de Valladolid

Valladolid, Spain, 47010

Study of Semaglutide, and Cilofexor/Firsocostat, Alone and in Combination, in Adults With Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH) (WAYFIND)

OVERVIEW

PROTOCOL SUMMARY

Participation Requirements

Eligibility Information

Inclusion Criteria

Exclusion Criteria

Locations

Locations (242)

University of Alabama at Birmingham Hospital

Digestive Health Specialists

North Alabama Health Research, LLC

The Institution For Liver Health dba Arizona Liver Health

Arizona Health Research

The Institute for Liver Health DBA Arizona Liver Health

Gastrointestinal Alliance - Sun City

Adobe Clinical Research, LLC

The Institution For Liver Health dba Arizona Liver Health

Arkansas Diagnostic Center

ARCare Center for Clinical Research

Arkansas Gastroenterology

Southern California Research Center

University of California, San Francisco - Fresno

University of California, San Diego - Altman Clinical and Translational Research Institute

Gastro Care Institute (Fibroscan)

Digestive Health Research of Southern California

Kaiser Permanente Los Angeles Medical Center

Keck Medical Center of USC Healthcare Consultation II

Biopharma Informatic, LLC

United Medical Doctors

Knowledge Research Center

Palmtree Clinical Research, Inc.

California Liver Research Institute

Cadena Care Institute, LLC

Stanford Medicine Outpatient Center

Inland Empire Clinical Trials

University of California, Davis Medical Center

Research and Education Inc.

TriWest Research Associates, LLC

Precision Research Institute

Medical Associates Research Group

Quest Clinical Research

University of California, San Francisco - Liver Clinic

San Jose Gastroenterology at One Health

University of Colorado Anschutz Medical Campus

South Denver Gastroenterology

Yale Center for Clinical Investigation, Church Street Research Unit

Excel Medical Clinical Trials, LLC

Synergy Healthcare

Southwest General Healthcare Center

University of Florida Hepatology Research at the Clinical and Translational Research Building

Velocity Clinical Research, Hallandale Beach

Evolution Clinical Research, INC

Indago Research and Health Center, Inc.

Maya Research Center

New Generation of Medical Research

Sunbright Health Medical Center

Nature Coast Clinical Research

UF Health Jacksonville-Gastroenterology Emerson

Encore Borland-Groover Clinical Research

Florida Research Institute

Ocean Blue Medical Research Center, Inc

G+C Research Group

Schiff Center for Liver Diseases/ University of Miami

Advanced Pharma CR, LLC

Century Research, LLC

ProLive Medical Research, Corp

International Medical Investigational Centers, Inc.

Gastroenterology Group of Naples

Advanced Research Institute, Inc.

Ocala GI Research

Advanced Medical Research Center

Progressive Medical Research

Covenant Metabolic Specialists, LLC

Charter Research

Florida Medical Clinic, LLC

Southeast Clinical Research LLC

Gastrointestinal (GI) Specialists of Georgia

Rush University Medical Group - Department of Hepatology