Study Details

OVERVIEW

Open-Label, Global, Multicenter, Randomized, Phase 3 Study of Sacituzumab Govitecan Versus Docetaxel in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Progression on or After Platinum-Based Chemotherapy and Anti-PD-1/PD-L1 Immunotherapy (EVOKE-01)

PROTOCOL SUMMARY

The goal of this clinical study is to compare the study drug, sacituzumab govitecan-hziy (SG), versus docetaxel in participants with advanced or metastatic (cancer that has spread) non-small cell lung cancer (NSCLC).

Participation Requirements

Age

18 Years +

Sex

All

Healthy Volunteers

Medical Condition

Non-Small Cell Lung Cancer

Gender

N/A

Date

November 2021 - November 2023

Study Type

Interventional

Study Phase

Phase 3

Product

Sacituzumab Govitecan-hziy (SG), Docetaxel

Eligibility Information

Inclusion Criteria

Pathologically documented non-small cell lung cancer (NSCLC) with documented evidence of Stage 4 NSCLC disease at the time of enrollment (based on the American Joint Committee on Cancer, Eighth Edition).
Epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and programmed death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) results are required. Testing prior to enrollment. Resulting for other actionable genomic alterations is recommended and to be performed as per local standard of care and availability of targeted treatment. For patients with squamous cell carcinoma, EGFR and ALK testing is optional.
Must have progressed after platinum-based chemotherapy in combination with anti-PD-1/PD-L1 antibody OR platinum-based chemotherapy and anti-PD-1/PD-L1 antibody (in either order) sequentially.
No additional treatments are allowed in the recurrent/metastatic setting for individuals with no actionable genomic alterations.
Individuals with EGFR, ALK, or any other known actionable genomic alterations must have also received treatment with at least 1 locally approved and available tyrosine kinase inhibitor 1(TKI) appropriate to the genomic alteration.
Documented radiographic disease progression while on or after receiving the most recent treatment regimen for advanced or metastatic NSCLC.
Measurable disease based on computed tomography (CT) or magnetic resonance imaging (MRI) as assessed by the investigator in accordance with per RECIST Version 1.1.
Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1 before randomization.
Adequate hematologic counts without transfusional or growth factor support within 2 weeks of study drug initiation (hemoglobin ≥ 9 g/dL, absolute neutrophil count ≥ 1500/mm^3, and platelets ≥ 100,000/μL).
Adequate hepatic function (bilirubin ≤ 1.5 x upper limit of normal (ULN), aspartate aminotransferase and alanine aminotransferase ≤ 2.5 ULN or ≤ 5 x ULN if known liver metastases, and serum albumin > 3 g/dL).
Creatinine clearance of at least 30 mL/min as assessed by the Cockcroft-Gault equation.
Male individuals and female individuals of childbearing potential who engage in heterosexual intercourse must agree to use protocol-specified method(s) of contraception.

Exclusion Criteria

Mixed small-cell lung cancer and NSCLC histology.
Positive serum pregnancy test or women who are lactating.
Received a prior anticancer biologic agent within 4 weeks prior to enrollment or have received prior chemotherapy, targeted small molecule therapy, or radiation therapy within 2 weeks prior to enrollment and have not recovered (ie, > Grade 2 is considered not recovered) from adverse events (AEs) at the time of study entry. Individuals participating in observational studies are eligible.
Have not recovered (ie, > Grade 2 is considered not recovered) from AEs due to a previously administered agent.
Previously received treatment with any of the following:
Topoisomerase 1 inhibitors. Any agent including an antibody-drug conjugate (ADC) containing a chemotherapeutic agent targeting topoisomerase 1
Trop-2-targeted therapy
Docetaxel as monotherapy or in combination with other agents
Active second malignancy
NSCLC that is eligible for definitive local therapy alone.
Clinically severe pulmonary compromise resulting from intercurrent pulmonary illnesses including, but not limited to, any underlying pulmonary disorder (ie, pulmonary emboli within 3 months of enrollment, severe asthma, severe chronic obstructive pulmonary disease, restrictive lung disease, pleural effusion, etc); any autoimmune, connective tissue, or inflammatory disorders with pulmonary involvement (ie, rheumatoid arthritis, Sjogren syndrome, sarcoidosis, etc); or prior pneumonectomy.
Known active central nervous system (CNS) metastases and/or carcinomatous meningitis.
Active cardiac disease
Active chronic inflammatory bowel disease (ulcerative colitis, Crohn's disease) or gastrointestinal perforation within 6 months of enrollment.
Active serious infection requiring antibiotics.
Positive HIV-1 or HIV-2 antibody with detectable viral load OR taking medications that may interfere with SN-38 metabolism.
Positive for hepatitis B surface antigen. Individuals who test positive for hepatitis B core antibody will require hepatitis B virus DNA by quantitative polymerase chain reaction for confirmation of active disease.
Positive hepatitis C antibody and detectable hepatitis C viral load.
Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Locations

Locations (227)

Alaska Oncology and Hematology, LLC.

Anchorage, Alaska, United States, 99508

USOR - Arizona Oncology Associates Tucson - Wilmot

Tucson, Arizona, United States, 85711

Beverly Hills Cancer Center

Beverly Hills, California, United States, 90211

Rocky Mountain Cancer Centers - Aurora

Aurora, Colorado, United States, 80012

Florida Cancer Specialists (Administration and Drug Shipment)

Fort Myers, Florida, United States, 33901

Woodlands Medical Specialists, PA

Pensacola, Florida, United States, 32503

Florida Cancer Specialists

Saint Petersburg, Florida, United States, 33705

Florida Cancer Specialists

West Palm Beach, Florida, United States, 33401

University of Chicago Medical Center

Chicago, Illinois, United States, 60607

Illinois Cancer Specialists

Niles, Illinois, United States, 60714

Siouxland Regional Cancer Center dba June E. Nylen Cancer Center

Sioux City, Iowa, United States, 51101

Kansas City VA Medical Center

Westwood, Kansas, United States, 66205

Baptist Health Lexington

Lexington, Kentucky, United States, 40503

Maryland Oncology Hematology, P.A.

Clinton, Maryland, United States, 20735

Lahey Hospital & Medical Center

Burlington, Massachusetts, United States, 01805

Park Nicollet Frauenshuh Cancer Center

Saint Paul, Minnesota, United States, 55101

Nebraska Hematology - Oncology

Lincoln, Nebraska, United States, 68506

Comprehensive Cancer Centers of Nevada

Henderson, Nevada, United States, 89052

Broome Oncology, LLC

Johnson City, New York, United States, 13790

Stony Brook Cancer Center

Stony Brook, New York, United States, 11794

Levine Cancer Institute

Charlotte, North Carolina, United States, 28204

FirstHealth Outpatient Cancer Center

Pinehurst, North Carolina, United States, 28374

W.G (Bill) Hefner VAMC

Salisbury, North Carolina, United States, 28144

Zangmeister Cancer Center

Columbus, Ohio, United States, 43219

Tennessee Oncology, PLLC

Chattanooga, Tennessee, United States, 37404

Baptist Clinical Research Institute

Memphis, Tennessee, United States, 38120

Texas Oncology - Bedford

Bedford, Texas, United States, 76022

Texas Oncology - Denison

Denison, Texas, United States, 75020

Texas Oncology - Denton South

Denton, Texas, United States, 76201

Texas Oncology Cancer Care and Research Center

McAllen, Texas, United States, 78503

USOR - Texas Oncology - McKinney

McKinney, Texas, United States, 75071

Texas Oncology - Paris

Paris, Texas, United States, 75460

Texas Oncology-Plano East

Plano, Texas, United States, 75075

Texas Oncology-Plano West

Plano, Texas, United States, 75093

Shenandoah Oncology Associates, PC

Winchester, Virginia, United States, 22601

University of Wisconsin Clinical Science Center

Madison, Wisconsin, United States, 53792

Froedtert Hospital/Medical College of Wisconsin

Milwaukee, Wisconsin, United States, 53226

Border Medical Oncology Research Unit

Albury, New South Wales, Australia, 2640

Southern Highlands Cancer Centre

Bowral, New South Wales, Australia, 2576

St Vincent's Public Hospital

Darlinghurst, New South Wales, Australia, 2010

Sunshine Coast University Private Hospital

Birtinya, Queensland, Australia, 4575

Gallipoli Medical Research Foundation

Greenslopes, Queensland, Australia, 4120

Flinders Medical centre

Bedford Park, South Australia, Australia, 5042

Icon Cancer Centre

Hobart, Tasmania, Australia, 7000

Box Hill Hospital

Box Hill, Victoria, Australia, 3128

Monash Health

Clayton, Victoria, Australia, 3168

Peninsula & South Eastern Haematology and Oncology Group

Frankston, Victoria, Australia, 3199

Joondalup Health Campus

Joondalup, Western Australia, Australia, 6027

ir Charles Gairdner Hospital

Perth, Western Australia, Australia, 6009

Medizinische Universität Innsbruck, Medizinische Universitat Innsbruck, Universitatsklinik fur Innere Medizin V, Hamatologie und Onkolgie

Innsbruck, Austria, 06020

Muellner Hauptstrabe 48

Salzburg, Austria, 5020

zuniklinikum Salzburg, Landeskrankenhaus, Universitatsklinik fur Innere Medizin III der PMU

Salzburg, Austria, A-5020

Klinik Floridsdorf, Karl Landsteiner Institute fur Lungenforschung und Pneumologische onkologie (LFPO) Abteilung Fur Innere Medizin un Pneumologie

Vienna, Austria, 1210

Algemeen Ziekenhuis Klina

Brasschaat, Belgium, 2930

Cliniques Universitaires Saint-Luc

Brussels, Belgium, 1200

Universitair Ziekenhuis Antwerpen

Edegem, Belgium, 2650

Algemeen Ziekenhuis Sint-Lucas

Gent, Belgium, 9000

Az Maria Middelares Ghent

Gent, Belgium, 9000

CHU Ambroise Pare

Mons, Belgium, 7000

CRIO - Centro Regional Integrado de Oncologia

Fortaleza, Brazil, 60810180

ONCOSITE - Centro de Pesquisa Clinica em Oncologia

Ijui, Brazil, 98700-000

Catatina Pesquisa Clinica - Clinica de Neoplasias Litoral

Itajai, Brazil, 88331-10

Centro de Pesquisas Clinicas da Fundacao Doutor Amaral Carvalho

Jau, Brazil, 17210080

Hospital de Clínicas de Porto Alegre - HCPA

Porto Alegre, Brazil, 90035903

Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa

Porto Alegre, Brazil, 90110-270

Instituto do Câncer do Estado de São Paulo "Octavio Frias de Oliveira" - ICESP

Sao Paolo, Brazil

Nucleo de Pesquisa da Rede Sao Camilo-Instituto Brasileiro de controle do cancer-IBC

Sao Paulo, Brazil, 03102002

A Beneficência Portuguesa de São Paulo

São Paulo, Brazil

Royal Victoria Regional Health Centre

Barrie, Canada, L4M 6M2

William Osler Health System-Brampton Civic Hospital

Brampton, Canada, L6R 3J7

McGill University Health Centre

Montreal, Canada, H4A 3J1

Required Centre Hospitalier Regional de Rimouski

Rimouski, Canada, G5L5T1

Windsor Regional Hospital Cancer Program

Windsor, Canada, N8W 2X3

Institut Sainte Catherine

Avignon, France, 84918

Centre Hospitalier de la Côte Basque

Bayonne, France, 64100

APHP-Hopital Ambroise-Pare

Boulogne-Billancourt, France, 92100

CHU de CAEN

Caen, France, 14033

Centre Francois Baclesse

Calvados, France, 14076 CEDEX 05

Centre Hospitalier de Chauny

Chauny, France, 02300

CHU-Hopital Gabriel Montpied

Clermont Ferrand, France, 63000

Centre Hospitalier Intercommunal de Creteil

Creteil, France, 94010

Centre Hospitalier Annecy Genevois

Epagny Metz-tessy, France, 74374

Centre Hospitalier Departemental Vendee

La Roche-sur-Yon, France, 85925

Clinique Victor Hugo

Le Mans, France, 72000

CHU de Lille

Lille, France, 59000

Hopital Dupuytren (CHU de Limoges)

Limoges cedex, France, 87042

Chu Montpellier Hopital Arnaud de Villeneuve

Montpellier, France, 34295 CEDEX

GHR Sud Alsace - Hopital Emile Muller

Mulhouse, France, 68100

Institut Curie

Paris cedex 05, France

CHU de Bordeaux Hopital Haut leveque

Pessac, France, 33600

Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud

Pierre Benite, France, 69495

CHU de Poitiers

Poitiers, France, 86021

Centre Hospitalier Universitaire de Rouen - Hopitel Charles Nicolle

Rouen, France, 76031

Institut de Cancérologie de l'Ouest - Paysde Loire (site SAINT HERBLAIN)

saint Herblain, France, 44805

Hopital Foch

Saint Herblain, France

Institut Cancérologie Strasbourg Europe

Strasbourg, France, 67033

CHITS-Hopital Sainte Musse

Toulon cedex, France, 83056

Stadtisches Klinikum Braunschweig gGmbH Medizinische Klinik III Hamatologie und Onkologie

Braunschweig, Germany, 38114

Klinikum Esslingen GmbH Klinik fur Kardiologie,Angiologie und Pneumologie

Esslingen, Germany, 73730

Asklepios Klinikum Harburg, Thoraxzentrum Hamburg - Lungenabteilung

Hamburg, Germany, 21075

Studiengeselischaft Hamato-Onkologie Hamburg

Hamburg, Germany

Onkologische Schwerpunktpraxis Heilbronn

Heilbronn, Germany, 74245

Lungenfachklink Immenhausen

Immenhausen, Germany, 34376

Klinikum Kassel Klinik Für Hämatologie Onkologie Und Immunologie

Kassel, Germany, 34125

Universitatsklinikum Schleswig-Holstein - Campus Lubeck, Medizinische Klinik III (Studienzentrum Pneumologie)

Lubeck, Germany, 23538

University Hospital Mannheim, Department of Personalized Medical Oncology with Section Thoracic Oncology

Mannheim, Germany, 68167

Asklepios-Fachkliniken Munchen-Gauting, Zentrum fur Pneumologie und Thoraxchirurgie

Munchen-Gauting, Germany, 82131

Sana Klinikum Offenbach, Medizinische Klinik IV fur Hamatologie und internistische Onkologie

Offenbach, Germany, 63069

Henry Dunant Hospital Center, 4th Oncology Department

Athens, Greece, 11526

General Hospital of Chest Diseases "I Sotiria", 3rd Internal Medicine Department of Athens University - Oncology Unit

Athens, Greece, 11527

Metropolitan General, Oncology department

Cholargos, Greece, 15562

General Oncology Hospital of Kifisia "Agioi Anargyroi", 2nd Department of Medical Oncology

Heraklion, Greece

University General Hospital of Larissa, Oncology Department-1St Internal Medical Division

Larisa, Greece, 413 34

General Oncology Hospital of Kifisia "Agioi Anargyroi", 2nd Department of Medical Oncology

Nea Kifisia, Greece, 14565

Euromedica General Clinic of Thessaloniki

Thessaloniki, Greece, 54645

Interbalkan Medical Center of Thessaloniki

Thessaloniki, Greece, 555 35

Samson Assuta Ashdod University Hospital

Ashdod, Israel, 7747629

Soroka Medical Center

Beer Seva, Israel, 84101

Hadassah University Hospital Ein Kerem

Jerusalem, Israel

Kaplan Medical Center

Rehovot, Israel, 76100

Tel Aviv Sourasky Medical Center

Tel Aviv, Israel

Shamir Medical Center (Assaf Harofeh)

Tzrifin, Israel

ASST Papa Giovanni XXIII, Oncologia Medica

Bergamo, Italy, 24127

Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia

Brescia, Italy, 25123

AOU Policlinico G Rodlico-Oncologia Medica

Catania, Italy, 95125

AOU mater Domini, UOC Oncologia Medica e Oncologia Medica Trazionale

Catanzaro, Italy, 88100

ASST Cremona

Cremona, Italy, 26100

Instituto Europeo di Oncologia

Milano, Italy, 20141

ASST Grande Ospedale Metropolitano Niguarda SC Oncologia

Milano, Italy, 20162

Fondazione IRCCS Policlinico San Matteo

Pavia, Italy, 27100

Fondazione Policlinico Universitario Campus Bio-Medico, UOC Oncologia Medica

Roma, Italy, 00128

UOC Oncologia

San Giovanni Rotondo, Italy, 71013

ASST Bergamo Ovest- ospedale di Treviglio-u.o. Oncologia

Treviglio, Italy, 24047

SC Oncologia -ASST SETTE LAGHI

Varese, Italy, 21100

National Hospital Organization Asahikawa Medical Center

Asahikawa, Japan, 070-8644

National Cancer Center Hospital

Chuo, Japan, 104-0045

Fukui Prefectural Hospital

Fukui, Japan, 910-8526

Kansai Medical University Hospital

Hirakata, Japan, 573-1191

Hiroshima University Hospital

Hiroshima, Japan, 734-8551

Kobe City Medical Center General Hospital

Hyogo, Japan, 650-0047

National Hospital Organization Himeji Medical Center

Hyogo, Japan, 670-8520

Nippon Medical School Chiba Hokusoh Hospital

Inzai, Japan, 270-1694

National Hospital Organization Iwakuni Clinical Center

Iwakuni, Japan, 740-8510

Kagoshima University Hospital

Kagoshima, Japan, 8908520

Kanagawa Prefectural Hospital Organization Kanagawa Cardiovascular and Respiratory Center

Kanagawaken, Japan, 236-0051

Kanazawa University Hospital

Kanazawa, Japan, 920-8641

National Cancer Center Hospital East

Kashiwa, Japan, 277-8577

Saitama Cancer Center

Kitaadachi-gun, Japan, 362-0806

The Cancer Institute Hospital of JFCR

Koto, Japan, 135-8550

Kurume University Hospital

Kurume, Japan, 830-0011

University Hospital Kyoto Prefectural University of Medicine

Kyoto, Japan, 602-8566

Shikoku Cancer Center

Matsuyama, Japan, 791-0280

Miyagi Cancer Center

Miyagi, Japan, 981-1293

Nagasaki University Hospital

Nagasaki, Japan, 852-8501

National Hospital Organization Nagoya Medical Center

Nagoya, Japan, 460-0001

Niigata Cancer Center Hospital

Niigata, Japan, 951-8566

Okayama University Hospital

Okayama, Japan, 700-8558

Kindai University Hospital

Osakasayama-Shi, Japan, 589-8511

Osaka Prefectural Hospital Organization Osaka International Cancer Institute

Osaka, Japan, 541-8567

National Hospital Organization Kinki-Chuo Chest Medical Center

Sakai, Japan, 591-8555

Centor Hospital of the National Center for Global Health and Medicine

Shinjuku-Ku, Japan, 162-8655

Shizuoka Cancer Center

Sunto-gun, Japan, 411-8777

National Hospital Organization Osaka Toneyama Medical Center

Toyonaka, Japan, 560-8552

Tochigi Cancer Center

Utsunomiya, Japan, 320-0834

Japanese Red Cross Wakayama Medical Center

Wakayama, Japan, 640-8558

Yokohama Municipal Citizen's Hospital

Yokohama, Japan, 221-0855

Kanagawa Cancer Center

Yokohama, Japan, 241-8515

Tottori University Hospital

Yonago, Japan, 683-8504

Cryptex Investigación Clínica, S.A. de C.V.

Ciudad de Mexico, Mexico, 06100

Panamerican Clinical Research S.A. de C.V

Guadalajara, Mexico, 44670

Actualidad Basada en la Investigación del Cáncer

Guadalajara, Mexico

Amphia Hospital

Breda, Netherlands, 4818 CK

Haaglanden Medical Centre

Den Haag, Netherlands, 2262BA

Maastricht Universitair Medisch Centrum

Maastricht, Netherlands, 6229 HX

Erasmus MC

Rotterrdam, Netherlands, 3015

Elisabeth-TweeSteden Ziekenhuis (ETZ)

Tilburg, Netherlands, 5022

Przychodnia Lekarska Komed Roman Karaszewski

Konin, Poland, 62-500

Instytut MSF Sp. z o.o.

Lodz, Poland, 90-302

Centrum Medyczne Mrukmed

Rzeszáw, Poland, 35-085

Marzowiecki Szpital Wojewodzki sw Jana Pawla II Wsiedicach sp. z.o.o Siedickie centrum onkoiogii

Siedlce, Poland, 08-110

Instituto Português de Oncologia de Coimbra Francisco Gentil

Coimbra, Portugal, 3000-075

Centro Hospitalar Universitário Lisboa Norte - Hospital Pulido Valente

Lisboa, Portugal, 1769-001

Fundacao Champalimaud

Lisbon, Portugal

Senhora da Hora

Matosinhos, Portugal, 4464-513

Hospital CUF Porto

Porto, Portugal, 14341

Centro Hospitalar Universitario do Porto

Porto, Portugal, 4099-001

Instituto Portugues de Oncologia do Porto

Porto, Portugal, 4200-072

Ad-Vance Medical Research, LLC

Ponce, Puerto Rico, 00717

Pan American Center For Oncology Trials, LLC

San Juan, Puerto Rico, 00902

Complejo Hospitalario Universitario A Coruna. Hospital Teresa Herrera

A coruna, Spain, 15006

Institut Catala d'Oncologia Badalona, ICO Badalona, Hospital Germans Trias i Pujol

Badalona, Spain, 08916

Hospital Universitario Cruces

Barakaldo, Spain, 48903

Hospital Universitari Dexeus

Barcelona, Spain, 08028

Hospital Universitario Vall D'Hebron

Barcelona, Spain, 08035

Institut Catala D'Oncologia (ICO L'Hospitalet) Hospital Duran i Reynals

Barcelona, Spain, 08908

Hospital San Pedro de Alcantara

Cáceres, Spain, 10004

Institut Catala d'Oncologia de Girona

Girona, Spain, 17007

Hospital Universitario de la Princesa

Madrid, Spain, 28006

Hospital Universitario Gregorio Marañón

Madrid, Spain, 28007

Hospital Universitario Fundacion Jimenez Dias

Madrid, Spain, 28020

Hospital Universitario Ramón y Cajal

Madrid, Spain, 28034

Hospital Clinical San Carlos

Madrid, Spain, 28040

Hospital Universitario 12 Octubre

Madrid, Spain, 28041

Hospital universitario la paz

Madrid, Spain, 28046

Hospital Regional Universitario de Malaga-Hospital Civil

Malaga, Spain, 29010

Hospital Clinicl universitario virgen de la Arrixaca

Murcia, Spain, 30120

Clinica Universidad de Navarra-Pamplona

Pamplona, Spain, 31008

Hospital de Sabadell

Sabadell, Spain, 8208

Hospital Virgen de Valme

Sevilla, Spain, 41001

Hospital universitario Virgen Macarena

Sevilla, Spain, 41009

Hospital Universitario la Fe

Valencia, Spain, 46026

Hacettepe Üniversitesi Hastanesi

Ankara, Turkey, 06230

Memorial Ankara Hastane

Ankara, Turkey, 06520

Acibadem Bursa Hastanesi

Bursa, Turkey, 16059

Ankara Sehir Hastanesi

Dikimevi- Ankara, Turkey, 06100

Trakya Üniversitesi Sağlık Araştırma ve Uygulama Merkezi

Edirne, Turkey

Bagcilar Medipol Mega Universite Hastanesi

Istanbul, Turkey

T.C. Saglik Bakanligi Goztepe Prof. Dr Suleyman Yalcin Sehir Hastanesi

Kadikoy, Turkey

Acibadem Maslak Hastanesi

Sariyer, Turkey

Gazi Universitesi Gazi Hastanesi

Yenimahalle, Turkey

University Hospital Birmingham NHS Trust, Birmingham Heartlands Hospital

Birmingham, United Kingdom, B9 5SS

East Suffolk and North Essex NHS Foundation Trust

Colchester, United Kingdom, CO4 5JL

The Beatson West of Scotland Cancer Centre

Glasgow, United Kingdom, G12 0YN

St James University Hospital

Leeds, United Kingdom, LS9 7TF

Leicester Royal Infirmary

Leicester, United Kingdom, LE1 5WW

Barts Health NHS Trust

London, United Kingdom, EC1A 7BE

The Christie NHS Foundation

Manchester, United Kingdom, M20 4BX

Study of Sacituzumab Govitecan (SG) Versus Docetaxel in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) (EVOKE-01)

OVERVIEW

PROTOCOL SUMMARY

Participation Requirements

Eligibility Information

Inclusion Criteria

Exclusion Criteria

Locations

Locations (227)

Alaska Oncology and Hematology, LLC.

USOR - Arizona Oncology Associates Tucson - Wilmot

Beverly Hills Cancer Center

Rocky Mountain Cancer Centers - Aurora

Florida Cancer Specialists (Administration and Drug Shipment)

Woodlands Medical Specialists, PA

Florida Cancer Specialists

Florida Cancer Specialists

University of Chicago Medical Center

Illinois Cancer Specialists

Siouxland Regional Cancer Center dba June E. Nylen Cancer Center

Kansas City VA Medical Center

Baptist Health Lexington

Maryland Oncology Hematology, P.A.

Lahey Hospital & Medical Center

Park Nicollet Frauenshuh Cancer Center

Nebraska Hematology - Oncology

Comprehensive Cancer Centers of Nevada

Broome Oncology, LLC

Stony Brook Cancer Center

Levine Cancer Institute

FirstHealth Outpatient Cancer Center

W.G (Bill) Hefner VAMC

Zangmeister Cancer Center

Tennessee Oncology, PLLC

Baptist Clinical Research Institute

Texas Oncology - Bedford

Texas Oncology - Denison

Texas Oncology - Denton South

Texas Oncology Cancer Care and Research Center

USOR - Texas Oncology - McKinney

Texas Oncology - Paris

Texas Oncology-Plano East

Texas Oncology-Plano West

Shenandoah Oncology Associates, PC

University of Wisconsin Clinical Science Center

Froedtert Hospital/Medical College of Wisconsin

Border Medical Oncology Research Unit

Southern Highlands Cancer Centre

St Vincent's Public Hospital

Sunshine Coast University Private Hospital

Gallipoli Medical Research Foundation

Flinders Medical centre

Icon Cancer Centre

Box Hill Hospital

Monash Health

Peninsula & South Eastern Haematology and Oncology Group

Joondalup Health Campus

ir Charles Gairdner Hospital

Medizinische Universität Innsbruck, Medizinische Universitat Innsbruck, Universitatsklinik fur Innere Medizin V, Hamatologie und Onkolgie

Muellner Hauptstrabe 48

zuniklinikum Salzburg, Landeskrankenhaus, Universitatsklinik fur Innere Medizin III der PMU

Klinik Floridsdorf, Karl Landsteiner Institute fur Lungenforschung und Pneumologische onkologie (LFPO) Abteilung Fur Innere Medizin un Pneumologie

Algemeen Ziekenhuis Klina

Cliniques Universitaires Saint-Luc

Universitair Ziekenhuis Antwerpen

Algemeen Ziekenhuis Sint-Lucas

Az Maria Middelares Ghent

CHU Ambroise Pare

CRIO - Centro Regional Integrado de Oncologia

ONCOSITE - Centro de Pesquisa Clinica em Oncologia

Catatina Pesquisa Clinica - Clinica de Neoplasias Litoral

Centro de Pesquisas Clinicas da Fundacao Doutor Amaral Carvalho

Hospital de Clínicas de Porto Alegre - HCPA

Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa

Instituto do Câncer do Estado de São Paulo "Octavio Frias de Oliveira" - ICESP

Nucleo de Pesquisa da Rede Sao Camilo-Instituto Brasileiro de controle do cancer-IBC

A Beneficência Portuguesa de São Paulo

Royal Victoria Regional Health Centre

William Osler Health System-Brampton Civic Hospital