LAST UPDATED
April 12, 2024
Clinicaltrials.gov ID
CTIS ID
CTIS ID
CTIS ID
CTIS ID
A Phase 2, Open-Label, Multicenter, Basket Study Evaluating the Efficacy of Brexucabtagene Autoleucel in Adults With Rare B-cell Malignancies (ZUMA-25) (ZUMA-25)
Master protocol: The goal of this master clinical study is to test how well the study drug, brexucabtagene autoleucel, works in participants with rare B-cell malignancies: relapsed/refractory Waldenstrom macroglobulinemia (r/r WM) (Substudy A - no longer recruiting), relapsed/refractory Richter transformation (r/r RT) (Substudy B), relapsed/refractory Burkitt lymphoma (r/r BL) (Substudy C and relapsed/refractory hairy cell leukemia (r/r HCL) (Substudy D - no longer recruiting).
View MoreAge
18 Years +
Sex
All
Healthy Volunteers
No
Medical Condition
Relapsed/Refractory Waldenstrom Macroglobulinemia, Relapsed/Refractory Richter Transformation, Relapsed/Refractory Burkitt Lymphoma, Relapsed/Refractory Hairy Cell Leukemia
Gender
N/A
Date
November 2022 - March 2025
Study Type
Interventional
Study Phase
Phase 2
Product
Brexucabtagene Autoleucel, Cyclophosphamide, Fludarabine
Duarte, California, United States, 91010
Stanford, California, United States, 94305
Denver, Colorado, United States, 80218
Washington, District of Columbia, United States, 20037
Iowa City, Iowa, United States, 52242
Boston, Massachusetts, United States, 02215
Saint Louis, Missouri, United States, 63110
Hackensack, New Jersey, United States, 07601
Columbus, Ohio, United States, 43210
Pittsburgh, Pennsylvania, United States, 15232
Nashville, Tennessee, United States, 37203
Nashville, Tennessee, United States, 37232
Houston, Texas, United States, 77030
Vienna, Austria, 01090
Paris, France, 75013
Toulouse Cedex 09, France, 31059
Heidelberg, Germany, 69120
Koln, Germany, 50937
Ulm, Germany, 89081
Bologna, Italy, 40138
Milano, Italy, 20162
Perugia, Italy, 06132
Nijmegen, Netherlands, 6525 GA
Barcelona, Spain, 08036
Salamanca, Spain, 37007
Sevilla, Spain, 41013
Bellinzona, Switzerland, 6500
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